眼外期：
（1）最早发生的是瘤细胞沿视神经向颅内蔓延，由于瘤组织的侵蚀使视神经变粗，如破坏了视神经孔骨质则视神经孔扩大，但在x线片上即使视神经孔大小正常，也不能除外球后及颅内转移的可能性。
（2）肿瘤穿破巩膜进入眶内，导致眼球突出；也可向前引起角膜葡萄肿或穿破角膜在球外生长，甚至可突出于睑裂之外，生长成巨大肿瘤。
青光眼期：由于肿瘤逐渐生长体积增大，眼内容物增加，使眼压升高，引起继发性青光眼，出现眼痛、头痛、恶心、呕吐、眼红等。儿童眼球壁弹性较大，长期的高眼压可使球壁扩张，眼球膨大，形成特殊的所谓"牛眼"外观，大角膜，角巩膜葡萄肿等，所以应与先天性青光眼等鉴别。
","barId":"1782","topicTypeId":"2","topicThemeId":"1029","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":1014,"score":0,"partCount":0,"replayCount":0,"publishStatus":1,"publishTime":1486617961348,"isCream":0,"canReply":0,"shareUrl":null,"foodCouponVal":1,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":1486617961346,"metaSearch":null,"rn":0,"barTitle":null,"checkcode":null,"forumUser":{"id":"3cc2575ce14111e6a61c00163e04584d","isDel":0,"createAt":1485158098983,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"username":"柠檬茶","password":"888888","level":0,"nickName":"柠檬茶","realName":null,"signName":"柠檬茶，我最爱","head":"http://01luntan.com/ly_img/1485160807561.jpg","phone":null,"mobile":null,"wechat":null,"qq":null,"email":null,"address":null,"identityType":6,"userType":2,"isPhoneBind":0,"status":0,"accountSource":0,"isStrangerMsg":0,"departmentId":null,"departmentName":null,"sex":1,"provinceId":"110000","cityId":"","userLevel":0,"modifyNameCount":1},"lyTopicReply":null,"createAtStr":null,"lyBar":null,"lyTopic":null},{"id":"1701","isDel":0,"createAt":1486617938253,"createBy":"3cc2575ce14111e6a61c00163e04584d","createName":"柠檬茶","updateAt":0,"updateBy":null,"updateName":null,"userId":"3cc2575ce14111e6a61c00163e04584d","title":"视网膜母细胞瘤眼内生长期有什么表现","content":" 眼内生长期：开始在眼内生长时外眼正常，因患儿年龄小，不能自述有无视力障碍，因此本病早期一般不易被家长发现。当肿瘤增殖突入到玻璃体或接近晶体时，瞳孔区将出现黄光反射，故称黑蒙性猫眼，此时常因视力障碍而瞳孔散大、白瞳症或斜视而家长发现。
眼底改变：可见圆形或椭圆形，边界清楚，单发或多发，白色或黄色结节 状隆起，表面不平，大小不一，有新生血管或出血点。肿瘤起源于内核层者，向玻璃体内生者叫内生型，玻璃体内可见大小不等的白色团块状混浊；起源于外核层者，易向脉络膜生长者叫外生型，常使视网膜发生无裂孔性实性扁平脱离。裂隙灯检查，前房内可能有瘤细胞集落，形成假性前房积脓、角膜后沉着物，虹膜表面形成灰白色肿瘤结节 ，可为早期诊断提供一些临床依据。
","barId":"1782","topicTypeId":"2","topicThemeId":"1029","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":919,"score":0,"partCount":0,"replayCount":0,"publishStatus":1,"publishTime":1486617938255,"isCream":0,"canReply":0,"shareUrl":null,"foodCouponVal":1,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":1486617938253,"metaSearch":null,"rn":0,"barTitle":null,"checkcode":null,"forumUser":{"id":"3cc2575ce14111e6a61c00163e04584d","isDel":0,"createAt":1485158098983,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"username":"柠檬茶","password":"888888","level":0,"nickName":"柠檬茶","realName":null,"signName":"柠檬茶，我最爱","head":"http://01luntan.com/ly_img/1485160807561.jpg","phone":null,"mobile":null,"wechat":null,"qq":null,"email":null,"address":null,"identityType":6,"userType":2,"isPhoneBind":0,"status":0,"accountSource":0,"isStrangerMsg":0,"departmentId":null,"departmentName":null,"sex":1,"provinceId":"110000","cityId":"","userLevel":0,"modifyNameCount":1},"lyTopicReply":null,"createAtStr":null,"lyBar":null,"lyTopic":null},{"id":"1541","isDel":0,"createAt":1486617920370,"createBy":"3cc2575ce14111e6a61c00163e04584d","createName":"柠檬茶","updateAt":0,"updateBy":null,"updateName":null,"userId":"3cc2575ce14111e6a61c00163e04584d","title":"视网膜母细胞瘤临床分类","content":"
临床表现
根据肿瘤的表现和发展过程一般可分四期。
1.眼内生长期：开始在眼内生长时外眼正常，因患儿年龄小，不能自述有无视力障碍，因此本病早期一般不易被家长发现。当肿瘤增殖突入到玻璃体或接近晶体时，瞳孔区将出现黄光反射，故称黑蒙性猫眼，此时常因视力障碍而瞳孔散大、白瞳症或斜视而家长发现。
眼底改变：可见圆形或椭圆形，边界清楚，单发或多发，白色或黄色结节 状隆起，表面不平，大小不一，有新生血管或出血点。肿瘤起源于内核层者，向玻璃体内生者叫内生型，玻璃体内可见大小不等的白色团块状混浊；起源于外核层者，易向脉络膜生长者叫外生型，常使视网膜发生无裂孔性实性扁平脱离。裂隙灯检查，前房内可能有瘤细胞集落，形成假性前房积脓、角膜后沉着物，虹膜表面形成灰白色肿瘤结节 ，可为早期诊断提供一些临床依据。
2.青光眼期：由于肿瘤逐渐生长体积增大，眼内容物增加，使眼压升高，引起继发性青光眼，出现眼痛、头痛、恶心、呕吐、眼红等。儿童眼球壁弹性较大，长期的高眼压可使球壁扩张，眼球膨大，形成特殊的所谓\"牛眼\"外观，大角膜，角巩膜葡萄肿等，所以应与先天性青光眼等鉴别。
3.眼外期：
（1）最早发生的是瘤细胞沿视神经向颅内蔓延，由于瘤组织的侵蚀使视神经变粗，如破坏了视神经孔骨质则视神经孔扩大，但在x线片上即使视神经孔大小正常，也不能除外球后及颅内转移的可能性。
（2）肿瘤穿破巩膜进入眶内，导致眼球突出；也可向前引起角膜葡萄肿或穿破角膜在球外生长，甚至可突出于睑裂之外，生长成巨大肿瘤。
4、全身转移期：转移可发生于任何一期，例如发生于视神经乳头附近之肿瘤，即使很小，在青光眼期之前就可能有视神经转移，但一般讲其转移以本期为最明显。转移途径：
（1）多数经视神经或眶裂进入颅内。
（2）经血行转移至骨及肝脏或全身其他器官。
（3）部分是经淋巴管转移到附近之淋巴结。
","barId":"1782","topicTypeId":"2","topicThemeId":"1029","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":880,"score":0,"partCount":0,"replayCount":0,"publishStatus":1,"publishTime":1486617920372,"isCream":0,"canReply":0,"shareUrl":null,"foodCouponVal":1,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":1486617920370,"metaSearch":null,"rn":0,"barTitle":null,"checkcode":null,"forumUser":{"id":"3cc2575ce14111e6a61c00163e04584d","isDel":0,"createAt":1485158098983,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"username":"柠檬茶","password":"888888","level":0,"nickName":"柠檬茶","realName":null,"signName":"柠檬茶，我最爱","head":"http://01luntan.com/ly_img/1485160807561.jpg","phone":null,"mobile":null,"wechat":null,"qq":null,"email":null,"address":null,"identityType":6,"userType":2,"isPhoneBind":0,"status":0,"accountSource":0,"isStrangerMsg":0,"departmentId":null,"departmentName":null,"sex":1,"provinceId":"110000","cityId":"","userLevel":0,"modifyNameCount":1},"lyTopicReply":null,"createAtStr":null,"lyBar":null,"lyTopic":null},{"id":"1309","isDel":0,"createAt":1486617892299,"createBy":"3cc2575ce14111e6a61c00163e04584d","createName":"柠檬茶","updateAt":0,"updateBy":null,"updateName":null,"userId":"3cc2575ce14111e6a61c00163e04584d","title":"视网膜母细胞瘤临床表现","content":"
临床表现：
1.早期无明显症状，可出现斜视。
2.眼底检查可发现肿瘤结节。
3.瞳孔白色反光或黄色反光（称为猫眼）
4.继发青光眼：肿瘤肿大突入玻璃体内使眼压增高，球结膜充血，瞳孔散大，眼球扩大变硬，患儿眼痛、头痛、啼哭。
5.眼外期：肿瘤向眼外转移。
6.全身转移期：向颅内及远处转移。
0
诊断依据：
1.小儿出现斜视，眼底检查发现大小不等的瘤结节。
2.白瞳或黄瞳（黑朦性猫眼）。
\n3.瞳孔散大，眼压增高，玻璃体内黄色反光，继发青光眼。
\n4.眼外及全身转移。
\n5.ｘ－线摄影、ｂ超、ｃｔ、核磁共振等检查可为临床提供依据。
\n6.术后病理检查可最后确诊。
\n","barId":"1782","topicTypeId":"2","topicThemeId":"1029","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":1077,"score":0,"partCount":0,"replayCount":0,"publishStatus":1,"publishTime":1486617869472,"isCream":0,"canReply":0,"shareUrl":null,"foodCouponVal":1,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":1486617869470,"metaSearch":null,"rn":0,"barTitle":null,"checkcode":null,"forumUser":{"id":"3cc2575ce14111e6a61c00163e04584d","isDel":0,"createAt":1485158098983,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"username":"柠檬茶","password":"888888","level":0,"nickName":"柠檬茶","realName":null,"signName":"柠檬茶，我最爱","head":"http://01luntan.com/ly_img/1485160807561.jpg","phone":null,"mobile":null,"wechat":null,"qq":null,"email":null,"address":null,"identityType":6,"userType":2,"isPhoneBind":0,"status":0,"accountSource":0,"isStrangerMsg":0,"departmentId":null,"departmentName":null,"sex":1,"provinceId":"110000","cityId":"","userLevel":0,"modifyNameCount":1},"lyTopicReply":null,"createAtStr":null,"lyBar":null,"lyTopic":null}],"list4Map":null,"pageBegin":0,"pageSize":25,"pageNumber":1,"totalPage":1,"totalRow":6},"focus":0,"userDtos":[],"currCount":0,"lyBar":{"id":"1782","isDel":0,"createAt":1483430773520,"createBy":"system","createName":"system","updateAt":0,"updateBy":null,"updateName":null,"userId":null,"name":"视网膜母细胞瘤","type":102,"twoCode":"http://zhao01.com/zly_img/zly_wx.jpg","image":null,"provinceId":null,"cityId":null,"illId":"4c8c5888badb11e6a61c00163e04584d","hospitalId":null,"keyWord":null,"totleTopic":0,"barDesc":null,"discussBarType":null,"metaSearch":"{\"channels\":{\"病友社区\":{\"description\":\"为您提供:视网膜母细胞瘤论坛_病友交流平台_病友论坛等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"视网膜母细胞瘤论坛_病友交流平台_病友论坛\",\"title\":\"视网膜母细胞瘤论坛_病友交流平台_病友论坛\"},\"治疗\":{\"description\":\"为您提供:视网膜母细胞瘤的治疗方法_视网膜母细胞瘤怎么治疗等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"视网膜母细胞瘤的治疗方法_视网膜母细胞瘤怎么治疗\",\"title\":\"视网膜母细胞瘤的治疗方法_视网膜母细胞瘤怎么治疗\"},\"症状\":{\"description\":\"为您提供:视网膜母细胞瘤的前兆_小儿视网膜母细胞瘤的症状等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"视网膜母细胞瘤的前兆_小儿视网膜母细胞瘤的症状\",\"title\":\"视网膜母细胞瘤的前兆_小儿视网膜母细胞瘤的症状\"},\"并发症\":{\"description\":\"为您提供:视网膜母细胞瘤的危害_视网膜母细胞瘤的后遗症等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"视网膜母细胞瘤的危害_视网膜母细胞瘤的后遗症\",\"title\":\"视网膜母细胞瘤的危害_视网膜母细胞瘤的后遗症\"},\"饮食\":{\"description\":\"为您提供:视网膜母细胞瘤吃什么好_视网膜母细胞瘤饮食禁忌等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"视网膜母细胞瘤吃什么好_视网膜母细胞瘤饮食禁忌\",\"title\":\"视网膜母细胞瘤吃什么好_视网膜母细胞瘤饮食禁忌\"},\"病因\":{\"description\":\"为您提供:怎么会视网膜母细胞瘤_视网膜母细胞瘤怎么引起的_视网膜母细胞瘤是什么等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"怎么会视网膜母细胞瘤_视网膜母细胞瘤怎么引起的_视网膜母细胞瘤是什么\",\"title\":\"怎么会视网膜母细胞瘤_视网膜母细胞瘤怎么引起的_视网膜母细胞瘤是什么\"},\"病友求助\":{\"description\":\"为您提供:视网膜母细胞瘤会痛吗_视网膜母细胞瘤生存率_视网膜母细胞瘤自愈等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"视网膜母细胞瘤会痛吗_视网膜母细胞瘤生存率_视网膜母细胞瘤自愈\",\"title\":\"视网膜母细胞瘤会痛吗_视网膜母细胞瘤生存率_视网膜母细胞瘤自愈\"},\"预防\":{\"description\":\"为您提供:视网膜母细胞瘤怎么预防_预防视网膜母细胞瘤的方法等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"视网膜母细胞瘤怎么预防_预防视网膜母细胞瘤的方法\",\"title\":\"视网膜母细胞瘤怎么预防_预防视网膜母细胞瘤的方法\"}},\"description\":\"为您提供:视网膜母细胞瘤原因_视网膜母细胞瘤症状_视网膜母细胞瘤治疗_视网膜母细胞瘤病友的治疗经验等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"视网膜母细胞瘤原因_视网膜母细胞瘤症状_视网膜母细胞瘤治疗\",\"title\":\"视网膜母细胞瘤原因_视网膜母细胞瘤症状_视网膜母细胞瘤治疗\"}","adInfo":null},"foodCouponValThan":null,"zlyTopic":{"id":"1782","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":null,"content":null,"barId":"1782","topicTypeId":null,"topicThemeId":"1029","readLevel":0,"files":null,"clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":null},"pageTopics":{"list":[],"list4Map":null,"pageBegin":0,"pageSize":10,"pageNumber":0,"totalPage":0,"totalRow":0},"herfList":[],"forumUserFocusBar":{"id":null,"isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"barId":null,"barName":null,"barType":0,"webType":0,"userType":0}}