{"countAll":0,"orderType":null,"readLevel":"0","lyTopicReq":{"id":"1930","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":null,"content":null,"barId":"1930","topicTypeId":null,"topicThemeId":"1026","readLevel":0,"files":null,"clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":null},"lyBarModerators":{"list":[],"list4Map":null,"pageBegin":0,"pageSize":8,"pageNumber":0,"totalPage":0,"totalRow":0},"metaSearch":{"description":"为您提供:类风湿性关节炎病因_引起类风湿关节炎原因_什么原因导致类风湿性关节炎等相关信息，让病友在便捷的求医路上不花一分冤枉钱。","keywords":"类风湿性关节炎病因_引起类风湿关节炎原因_什么原因导致类风湿性关节炎","title":"类风湿性关节炎病因_引起类风湿关节炎原因_什么原因导致类风湿性关节炎","channels":null},"data":{"list":[{"id":"10350","isDel":0,"createAt":1515037762040,"createBy":"8abb11d0af1511e7a3d800163e04584d","createName":"良药苦口","updateAt":0,"updateBy":null,"updateName":null,"userId":"8abb11d0af1511e7a3d800163e04584d","title":"类风湿关节炎原因以及发病机理","content":"

\"类风湿关节炎原因以及发病机理\"

 

类风湿关节炎(rheumatoid arthritis，RA)是关节滑膜及其周围的组织发炎，而且关节本身充满渗出液和白细胞，临床表现为关节肿胀、疼痛和僵硬，并且症状会出现于全身多个关节。了解其发病机理有助于治疗，早日康复。

 

发病机理

 

尚未完全明确，认为RA是一种自身免疫性疾病已被普遍承认。具有HLA-DR4和DW4型抗原者，对外界环境条件、病毒、细菌、神经精神及内分泌因素的刺激具有较高的敏感性，当侵袭机体时，改变了HLA的抗原决定簇，使具有HLA的有核细胞成为免疫抑制的靶子。由于HLA基因产生可携带T细胞抗原受体和免疫相关抗原的特性，当外界刺激因子被巨噬细胞识别时，便产生T细胞激活及一系列免疫介质的释放，因而产生免疫反应。

 

细胞间的相互作用使B细胞和浆细胞过度激活产生大量免疫球蛋白和类风湿因子（RF）的结果，导致免疫复合物形成，并沉积在滑膜组织上，同时激活补体，产生多种过敏毒素（C3a和C5a趋化因子）。局部由单核细胞、巨噬细胞产生的因子如IL-1、肿瘤坏死因子a、和白三烯B4，能刺激我形核白细胞移行进入滑膜。局部产生前列腺素E2的扩血管作用也能促进炎症细胞进入炎症部位，能吞噬免疫复合物及释放溶酶体，包括中性蛋白酶和胶原酶，破坏胶原弹力纤维，使滑膜表面及关节软骨受损。RF还可见于浸润滑膜的闪细胞，增生的淋巴滤泡及滑膜细胞内，同时也能见到IgG-RF复合物，故即使感染因素不存在，仍能不断产生RF，使病变反应发作成为慢性炎症。


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\"类风湿关节炎是怎么得的

 

类风湿性关节炎是一种慢性全身性炎症性疾病，可能与内分泌、代谢、营养、职业、遗传因索等方面有关系。让我们一起来认识风湿性关节炎。

 

患类风湿性关节炎的人越来越多，可能造成患者不同程度的残废、肾病和心脏病等疾病。所以及时治疗类风湿性关节炎非常有必要。本文将为您介绍类风湿性关节炎的危害、引起的原因及日常护理。

 

类风湿性关节炎的危害

 

1、类风湿关节炎可引发肾病：类风湿关节炎出现肾功能障碍，多与长期使用抗类风湿约和非甾体消炎镇痛约有关，虽然进展缓慢，但可导致肾功能衰竭。

 

2、可造成不同程度的残废：类风湿患者因为关节肿痛和运动受限，所以关节附近的肌肉容易僵硬和萎缩，可造成不同程度的残废，甚至对患者的心里造成极大的伤害。

 

3、类风湿关节炎可引发心脏病：类风湿关节炎并发心包炎可高达20%～50%，少数还形成类风湿结节，多数无症状，往往在心脏超声检查时发现。但也有引起左心衰竭的可能。

 

引起类风湿性关节炎的原因

 

1、寒冷、潮湿是一个诱发类风湿关节炎的重要因素。如果长期居住在潮湿的环境中，机体内环境平衡失调，分泌炎性细胞因子增多，引起炎性反应，这也是引发类风湿关节炎的原因。

 

2、空调的环境是凉爽和干燥，而且时间不长，一般是炎热的夏季，所以，使用空调一般不会得类风湿关节炎。不过，空调的温度不宜太低，一次吹的时间不宜太长，以免得“空调病”。

 

3、吸烟会使男性患类风湿关节炎的危险增加1倍，但却不会增加女性患类风湿关节炎的危险。研究人员推测，雌激素可能是造成吸烟不会增加女性患类风湿关节炎的原因。

 

4、绝经期雌激素缺乏能够影响类风湿关节炎患者的症状和体征，也能影响炎症水平。在一些病例中，绝经期综合征患者体内雌激素缺乏可能会导致类似类风湿关节炎的关节症状。

 

类风湿性关节炎的日常护理

 

1、在急性期，或关节疼痛肿胀严重者应绝对卧床休息。

 

2、慢性期或疼痛减轻者可适当活动，切不可因关节疼痛而放弃功能锻炼。

 

3、局部关节病变可进行局部按摩、被动活动等。


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\"类风湿性关节炎是怎么回事\" 

找良医网向您详细介绍类风湿性关节炎的病理病因，类风湿性关节炎主要是由什么原因引起的。

 

类风湿性关节炎病因

 

类风湿性关节炎具体病因尚未完全明确，目前认为其病因与环境因素、病感染、遗传、性激素及神经精神状态等因素密切相关：

 

① 遗传因素：本病在某些家族中发病率较高，在人群调查中，发现人类白细胞抗原(HLA)-DR4与RF阳性患者有关。HLA研究发现DW4与RA的发病有关，患者中70%HLA-DW4阳性，患者具有该点的易感基因，因此遗传可能在发病中起重要作用。

 

② 感染：病毒、细菌、支原体可能诱发RA发病。研究表明，EB病毒感染所致的关节炎与RA不同，RA病人对EB病毒比正常人有强烈的反应性。在RA病人血清和滑膜液中出现持续高度的抗EB病毒mdash;胞膜抗原抗体，但到目前为止在RA病人血清中一直未发现EB病毒核抗原或壳体抗原抗体。

 

③ 神经内分泌因素：女性患者月经前雌激素水平增高时，症状加重，月经后症状减轻。RA患者在不良因素刺激后，容易导致症状反复或病情加重。

 

④ 其他：寒冷、潮湿、疲劳、营养不良、创伤、精神因素等，常为本病的诱发因素，但多数患者前常无明显诱因可查。


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    骨关节炎是人类最古老和最常见的疾病。骨关节炎导致关节软骨破坏，引起关节疼痛和僵直。骨性关节炎还经常被称作关节退行性疾病、关节病、骨关节病或增生性关节炎。系列情况可以诱发骨性关节炎：身体过重、关节损伤、肌肉无力、关节区神经损伤、滑膜疾病和遗传病。

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\"关节炎的症状、骨关节炎的病因\" 

\n

    骨性关节炎可以发病与任何关节，手的小关节和第一掌跖关节比较多发，一般情况下也会常常影响髋关节、膝关节和脊柱。骨性关节炎很少累及腕、肘和踝关节除非是受了外伤或非正常压迫。

\n

 

\n

    大约有将近2100万美国人有骨关节炎。发病率随年龄增长而递增，男女在发病率方面没有什么分别。45岁以前，男性患病居多，45岁以后则是女性患病居多。

\n

 \"关节炎的症状、骨关节炎的病因\"

\n

    虽然有数百万人患有骨性关节炎，但严重影响生活工作的只是一小部分。骨关节炎虽然严重但可以治疗的疾病---很多患者在治疗后明显得到了改善。正确的诊断，和您的医生一起制定最适合您的治疗方案是很重要的。

\n

 

\n

    在正常的关节，每根骨头的末段都覆盖着坚硬而又有弹性的软骨。软骨为关节的活动提供光滑的表面，在骨头中间起软垫的作用。骨性关节炎患者的软骨被破坏就会导致关节的疼痛、肿胀和活动障碍。

\n

 \"关节炎的症状、骨关节炎的病因\"

\n

骨关节炎软骨的破坏一般分为几期：

\n

 

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1．随着年龄增长，软骨的结构开始改变，软骨的弹性逐渐丧失，更容易受到外伤和过分使用的损害。发生这种改变的时间和范围受遗传、关节外伤和其他因素的影响。

\n

 

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2．由于软骨的破坏导致滑膜的炎症，炎症产生细胞因子会进一步破坏软骨的酶。

\n

 

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3．随着软骨的破坏，其下的骨头暴露，关节就会丧失了自然的形态，最终骨头变厚形成骨性增生---骨刺。

\n

 

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4．关节附近的骨质中形成充满液体的小囊，关节腔内漂浮着骨头或软骨的小碎片，更会加重滑膜的炎症。

\n

 

\n

    除了软骨的破坏，关节腔内的液体（滑膜液）对疾病的发生也起了一定的作用。在正常关节，滑膜液对关节的正常活动起了必不可少的润滑作用。滑膜液是由一种叫作透明质酸的物质组成的。骨性关节炎患者的透明质酸量比正常多，但浓度低，性质也有所改变，也会降低对关节的保护功能。

\n

 

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   类风湿性关节炎已成为非常普遍的关节疾病，素有“不死的癌症”之说。据统计，每10000个人中就有30例个案。女性发病的机会是男性的3倍至5倍，而吸烟者发病的机会可以是非吸烟者的4倍！患病两年致残率更高达50%！许多人饱受类风湿病痛的折磨，苦不堪言。更让人寝食难安的是，类风湿性关节炎的病因，目前医学界仍无定论。患者对类风湿性关节炎的初期表现征兆也往往难以察觉！发病早期，关节受累多从四肢远端一两个小关节开始，以后再累及其他关节，如果早期不注意预防和治疗，那么随着病情的缓慢发展，将破坏关节内部软骨，进而出现活动功能障碍，畸形残废，卧床不起，生活无法自理，疼痛不堪，成为身体健康的“残酷杀手”！

   那么，现阶段我们是如何进行类风湿性关节炎的治疗呢？

   现阶段，医院对类风湿性关节炎的最强力的治疗药物一般都是采用激素类药物，如糖皮质激素，包括强的松、强的松龙及地塞米松等。尽管如此，用激素治疗类风湿性关节炎，仍不能阻断类风湿性关节炎的病情进展和关节破坏，而且，长期应用还会产生明显的副作用，如水肿、高血压、糖尿病、月经紊乱、肾上腺皮质机能低下、骨质疏松、细菌或病毒感染、无菌性骨坏死等，事实上，这些危害并不小于类风湿性关节炎本身的危害，长期使用还会产生依赖性并进一步破坏人体免疫系统，病情变本加厉起来。

   手术是不得已的治疗方法，其巨大风险让不少患者望而却步。现阶段的手术治疗包括滑膜切除术、关节镜下微创手术、关节矫形术、关节融合术等等，但是不能完全消除疼痛，而且手术的副作用和并发症较多，有一定的风险，诸如晚期感染，晚期关节松动，假体磨损等。类风湿性关节炎是全身免疫性疾病，全身关节都会受累，即使在手术成功的情况下，患者还要继续进行长期的药物治疗，而疾病的进一步恶化，也会造成其他关节继续被破坏。

   类风湿性关节炎患者被疾病和药物的双重矛盾所折磨，都期望能寻找到一种更加自然的、更加趋于彻底治愈的办法。与此同时，医学研究人员发现，类风湿性关节炎患者在用激素治疗期间，即使临床症状和化验检查都有好转，但关节组织的核心--软骨的破坏却在加剧，软骨中侵蚀入本来不该出现的新生血管。所以治疗的关键就在软骨，而促进软骨再生以及抑制新生血管就成为类风湿性关节炎治疗的焦点！

   那么，人类能否实现这种医学突破，重拾自由健康的生活呢？在欧美日等发达国家，Alternative Medicine -“代替医疗”应运而生，越来越多的代替医疗机构相继成立，在全世界范围内形成了一个新的医学潮流。而锯峰齿鲛软骨粉，在针对类风湿性关节炎“痛在关节，病在软骨”方面，表现出其促进软骨再生和抑制新生血管的优越性。

   锯峰齿鲛，俗称大青鲨。锯峰齿鲛软骨粉，顾名思义就是其软骨磨成的粉末。日本代替医疗学会研究证实：锯峰齿鲛软骨具有促进软骨再生，抑制新生血管的功效。2004年，国际著名的藤沼医院曾经做过一项临床实验统计：200名关节疾病患者（分别为被诊断患有类风湿性关节炎、风湿性关节炎、退行性关节炎、腰椎间盘突出等没有理想疗效的患者）在该医院院长藤沼秀光博士的指导下，每天服用7.5克的锯峰齿鲛软骨粉，3月后复检发现198人的关节疾病都有了改善，并且毫无副作用表现！

   这一临床数据举世瞩目，越来越多的医院将锯峰齿鲛软骨粉运用于临床，十多年来，锯峰齿鲛已经使日本近四十万人摆脱了关节疾病的痛苦，重新恢复自在生活。这种热烈推崇甚至造就了行业龙头企业--株式会社百傲鲨创造了辉煌的市场神话：占据日本市场95%份额的奇迹！并且促使它的名声在包括中国在内的亚洲各国中广为传播。2011年5月24日，在比利时首都布鲁塞尔的Autoworld博物馆举办的世界精品大会（Monde Selection）上，百傲鲨纯天然锯峰齿鲛软骨粉再传佳讯：继去年荣获该会银质大奖之后，2011年大会上百傲鲨再获金质大奖！

   目前，中国的医院对类风湿性关节炎的治疗仍在消炎止痛、手术以及副作用后遗症威胁的困境中踯躅不前，而千千万万类风湿性关节炎患者仍在期盼新的医学科技能把他们从痛苦中解脱出来。在欧美日等发达国家中，代替医疗正方兴未艾。人们越来越拒绝药剂和手术对人体的副作用，转而崇尚关注人体自愈力的代替医疗，代替医疗越来越受到国家的重视，许多代替医疗研究机构纷纷设立。相信在不久的将来，中国医学也将开启一个代替医疗的新时代，让更多的患者享受代替医疗带来的福利！


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