{"nowTime30":1790083043027,"lyBarModerator":null,"metaSearch":{"description":"很多糖尿病人都不知道什么是三多一少，那么，糖前有三多一少症状吗？没有三多一少的症状，就不会有糖尿病吧？找良医网告诉你，我们常说“三多一少”（多饮、多食、多尿、消瘦）是糖尿病的症状，但很多患者并没有这些典型症状。多数人可能只表现为疲劳、乏力、皮肤瘙痒等不典型的症状，甚至没有什么症状。所以，有典型症状的","keywords":"糖前有三多一少症状吗_洞医","title":"糖前有三多一少症状吗_洞医","channels":null},"identificate":{"id":null,"isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"realName":null,"certifiedStatus":0,"phone":null,"email":null,"hospitalId":null,"departmentId":null,"illName":null,"illId":null,"cardType":0,"cardImg":null,"idCardImg":null,"identityType":0,"stop":0,"departmentName":null,"hospitalName":null},"canEdit":null,"adList":[],"lyBar":{"id":"1935","isDel":0,"createAt":1483430801437,"createBy":"system","createName":"system","updateAt":0,"updateBy":null,"updateName":null,"userId":null,"name":"糖尿病","type":102,"twoCode":"http://zhao01.com/zly_img/zly_wx.jpg","image":null,"provinceId":null,"cityId":null,"illId":"06585752badb11e6a61c00163e04584d","hospitalId":null,"keyWord":null,"totleTopic":0,"barDesc":null,"discussBarType":null,"metaSearch":"{\"channels\":{\"病友社区\":{\"description\":\"为病友提供:糖尿病论坛_2型糖尿病论坛__病友交流平台_病友论坛，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"糖尿病论坛_2型糖尿病论坛__病友交流平台_病友论坛\",\"title\":\"糖尿病论坛_2型糖尿病论坛__病友交流平台_病友论坛\"},\"治疗\":{\"description\":\"为您提供:糖尿病的治疗方法_糖尿病的自我疗法有哪些等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"糖尿病的治疗方法_糖尿病的自我疗法有哪些\",\"title\":\"糖尿病的治疗方法_糖尿病的自我疗法有哪些\"},\"症状\":{\"description\":\"为您提供:糖尿病的早期症状有哪些_糖尿病的症状有哪些等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"糖尿病的早期症状有哪些_糖尿病的症状有哪些\",\"title\":\"糖尿病的早期症状有哪些_糖尿病的症状有哪些\"},\"并发症\":{\"description\":\"为您提供:糖尿病并发症有哪些_糖尿病并发症足病_糖尿病眼睛并发症前兆等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"糖尿病并发症有哪些_糖尿病并发症足病_糖尿病眼睛并发症前兆\",\"title\":\"糖尿病并发症有哪些_糖尿病并发症足病_糖尿病眼睛并发症前兆\"},\"饮食\":{\"description\":\"为您提供:糖尿病人吃什么水果好的快_糖尿病人饮食禁忌_高血糖饮食禁忌等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"糖尿病人吃什么水果好的快_糖尿病人饮食禁忌_高血糖饮食禁忌\",\"title\":\"糖尿病人吃什么水果好的快_糖尿病人饮食禁忌_高血糖饮食禁忌\"},\"病因\":{\"description\":\"为您提供:糖尿病是怎么引起的___糖尿病是什么原因引起的等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"糖尿病是怎么引起的___糖尿病是什么原因引起的\",\"title\":\"糖尿病是怎么引起的_糖尿病是什么原因引起的\"},\"病友求助\":{\"description\":\"为您提供:糖尿病一般能活多少年_怎么控制糖尿病_糖尿病现在能治好吗等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"糖尿病一般能活多少年_怎么控制糖尿病_糖尿病现在能治好吗\",\"title\":\"糖尿病一般能活多少年_怎么控制糖尿病_糖尿病现在能治好吗\"},\"预防\":{\"description\":\"为您提供:怎样预防糖尿病的发生_糖尿病预防和注意事项_遗传糖尿病如何预防等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"怎样预防糖尿病的发生_糖尿病预防和注意事项_遗传糖尿病如何预防\",\"title\":\"怎样预防糖尿病的发生_糖尿病预防和注意事项_遗传糖尿病如何预防\"}},\"description\":\"为您提供:男性糖尿病早期症状自查_1型、2型糖尿病的治疗方法_糖尿病吃什么水果_糖尿病病友的治疗经验等相关信息，让病友在便捷的求医路上不花一分冤枉钱。\",\"keywords\":\"男性糖尿病早期症状自查_1型、2型糖尿病的治疗方法_糖尿病吃什么水果\",\"title\":\"男性糖尿病早期症状自查_1型、2型糖尿病的治疗方法_糖尿病吃什么水果\"}","adInfo":null},"isLikeThisTopic":null,"lastTopics":[{"id":"25470","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":"糖尿病患者需要注意哪些事项","content":"<p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">糖尿病患者最大的威胁就是心脑血管疾病(如冠心病、心肌梗死、脑梗死等)。因此，预防控制好心脑血管疾病是糖尿病患者的首要任务。首先，糖尿病患者应在医生指导下接受正规的降糖治疗。但对于多数患者而言，仅仅关注血糖是不够的，糖尿病患者还需要注意哪些事项呢？</span></p><p style=\"line-height: 200%; text-align: center;\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">&nbsp;<img src=\"http://01luntan.com/ly_img/uimgs/1557408639055.jpg\" title=\"糖尿病患者需要注意哪些事项\" alt=\"糖尿病患者需要注意哪些事项\" width=\"600\" height=\"397\"/></span></p><p style=\"line-height:200%\"><strong><span style=\"font-size:19px;line-height:200%;font-family:宋体\">生活方式管理</span></strong></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">主要内容包括合理饮食、适量运动、控制体重、限制饮酒、戒烟等。首先，合理的饮食结构与总热量摄入不仅是降糖治疗的基石，也是降低心血管系统整体风险水平的有效措施，因而适用于所有糖尿病患者。对于超重（体质指数≥24kg/m2）/肥胖（体质指数≥28kg/m2）的患者，应以低碳水化合物、低脂肪饮食为主。其次，适量运动有助于控制体重、改善糖代谢和脂代谢状态并降低血压水平，对心血管系统具有有益影响。建议糖尿病患者坚持规律性的中等强度有氧运动（例如快步行走、太极拳、自行车运动等）。体重在正常范围者每日运动时间不少于30分钟，每周不少于5天。超重/肥胖者需要增加运动量，每日运动时间不少于1小时，每周不少于5天。若无禁忌证，应鼓励患者每周进行2-3次阻抗训练（如俯卧撑、仰卧起坐、下蹲运动、举哑铃等）。第三，吸烟可以增高不良心血管事件的危险性，因此吸烟者应努力戒烟。</span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">&nbsp;</span></p><p style=\"line-height:200%\"><strong><span style=\"font-size:19px;line-height:200%;font-family:宋体\">血压管理</span></strong></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">当糖尿病患者血压水平高于130/80 mmHg时，其不良心血管事件发生率将显著增高，因此多数患者的血压应控制在此水平以下。但是对于高龄、一般健康状况较差或已经发生严重心脑血管疾病的患者，过于严格的血压控制可能会对患者产生不利影响，将血压控制在140/90 mmHg以下就可以了。降压药物可以首选普利类或沙坦类，血压不能达标时可以联合应用地平类或利尿剂等。</span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">&nbsp;</span></p><p style=\"line-height:200%\"><strong><span style=\"font-size:19px;line-height:200%;font-family:宋体\">血脂管理</span></strong></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">对于已经发生心脑血管疾病的患者，无论其血脂水平如何，均应接受他汀治疗，将低密度脂蛋白胆固醇（LDL-C）控制在1.8mmol/L以下。没有心脑血管疾病但年龄≥40岁的患者，虽然其血脂水平不高也应该服用他汀类药物，将LDL-C控制于2.6 mmol/L以下。换言之，多数2型糖尿病患者需要接受他汀治疗。</span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">&nbsp;</span></p><p style=\"line-height:200%\"><strong><span style=\"font-size:19px;line-height:200%;font-family:宋体\">抗血小板治疗</span></strong></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">若无禁忌证，所有合并心脑血管疾病的患者均应服用小剂量阿司匹林（75-150 mg/d）。具有使用阿司匹林适应证但不能耐受治疗者，可应用氯吡格雷替代（75 mg/d）。无心脑血管疾病的50岁以上男性与60岁以上女性患者且伴有至少1项其他危险因素（吸烟，高血压，血脂异常，早发冠心病家族史，蛋白尿）者，若其不存在出血性并发症的高危因素（既往有胃肠道出血史或消化性溃疡病史，或正在服用非甾体类抗炎药物或华法林等增加出血风险的药物），也建议服用小剂量（75-150 mg/d）阿司匹林。</span></p><p style=\"line-height: 200%; text-align: center;\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\"><img src=\"http://01luntan.com/ly_img/uimgs/1557408759125.jpg\" title=\"糖尿病患者需要注意哪些事项\" alt=\"糖尿病患者需要注意哪些事项\" width=\"250\" height=\"343\"/></span></p><p style=\"line-height: 200%; text-align: center;\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">欢迎扫描二维码加入QQ群，听听病友们怎么说，听听医生怎么说</span></p><p><br/></p>","barId":"1935","topicTypeId":null,"topicThemeId":"1036","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":1,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":7},{"id":"25525","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":"糖尿病患者的饮食指导","content":"<p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">糖尿病作为一种慢性病，发病率逐年升高，是心脑血管病的独立危险因素，严重威胁着人们的生命安全。本文中，找良医网为你解答</span></span><strong><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">糖尿病患者的饮食指导</span></span></strong><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">。要知道的是，饮食不合理有时是糖尿病发生的直接原因；同时饮食治疗也是糖尿病治疗的最基本手段，是一切治疗的基础。控制糖尿病从控制饮食开始。</span></span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><img src=\"http://01luntan.com/ly_img/uimgs/1557910618756.jpg\" title=\"糖尿病患者的饮食指导\" alt=\"糖尿病患者的饮食指导\" width=\"600\" height=\"372\"/>&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">1.首要原则:控制食物的总热量</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">热量摄入量以达到或维持理想体重为宜。</span></span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">2.主食不宜控制过严</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">谷类中的淀粉为多糖，不会使血糖急剧增加，并且饱腹感强，应作为热量的主要来源。要严格限制含单糖和双糖的食物，如含葡萄糖、果糖、蔗糖、麦芽糖的食物及蜂蜜等。适度限制精加工米面，注意细粮粗做，粗细搭配，饭吃八分饱，吃动两平衡，能帮助人们将体重和血压维持在健康水平。</span></span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">3.限制脂肪摄入量</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">超重使成人和儿童同样面临患</span>2型糖尿病的危险。低脂饮食能帮助人们控制体重，从而减少糖尿病的危险因素。过多摄入脂肪还会增加胰岛素抵抗，降低胰岛素敏感性，使血糖升高。如果你已经是糖尿病患者，减少脂肪摄入有助于疾病的控制和避免其他相关健康问题。</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">4.蛋白质的摄入可按正常标准</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">糖尿病患者糖异生作用增强，蛋白质消耗增加，应适当增加蛋白质供给。成人按每天</span>1.0～1.2克/千克体重的标准摄取，并且优质蛋白质应该大于摄取蛋白质总量的1/2。</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">5.增加膳食纤维的摄入量</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">膳食纤维有助于预防和治疗糖尿病，有平稳血糖和改善糖耐量、保持大便畅通并减少饥饿感的作用，每天最好摄入</span>20克以上。粗杂粮、蔬菜、水果等食物中膳食纤维的含量较丰富。</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">6.增加维生素和矿物质的摄入</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">糖尿病患者尿量较多，容易出现</span>B族维生素丢失，应注意补充。铬、锰、锌等元素有助于改善糖尿病患者脂质代谢紊乱。</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">7.坚持定时定量进餐，提倡少食多餐</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">少食多餐既能保证营养充足，又能减轻胰腺负担，有利于控制血糖。建议每日</span>4～5餐为宜。定时定量进餐使血糖不会波动太大，还可有效预防低血糖。限制饮酒。</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">控制血糖跟控制高血压一样，不能仅限于药物的增减，非常需要慢病管理的五大处方：药物、运动、营养、心理睡眠和戒烟限酒。用好五大处方的组合拳，可用更少品种、更小剂量的药物，实现更好更稳定的血糖控制，而且减少药物副作用，节省医药费用。</span></span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><img src=\"http://01luntan.com/ly_img/uimgs/1557909997556.JPG\" title=\"糖尿病患者的饮食指导\" alt=\"糖尿病患者的饮食指导\" width=\"219\" height=\"300\"/>&nbsp;</span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">欢迎扫描二维码加入</span>QQ群，听听病友们怎么说，听听医生怎么说！</span></p><p><br/></p>","barId":"1935","topicTypeId":null,"topicThemeId":"1035","readLevel":0,"files":"[]","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":7},{"id":"25668","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":"糖尿病前期症状与危害","content":"<p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">糖尿病前期症状有哪些，危害有哪些？</span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">1. </span><span style=\"font-size:19px;line-height:200%;font-family:宋体\">什么是糖尿病前期？</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">我们知道，健康人空腹血糖的正常值是3.9~6.1 mmol/L，口服75克葡萄糖2小时后的血糖不应超过7.8 mmol/L。如果空腹血糖≥7.0mmol/L、或者口服75克葡萄糖2小时后血糖≥11.1 mmol/L，就考虑诊断为糖尿病。</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">如果一个人的血糖超过前述正常值但又未达到诊断糖尿病的标准，就称之为糖尿病前期。这就是说，如果你的空腹血糖超过6.1但未达到7.0 mmol/L，或者服葡萄糖后2小时血糖超过7.8但未达到11.1 mmol/L，均可称为糖尿病前期。</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">还有一个检测指标能够反映血糖水平，叫做糖化血红蛋白。在欧美国家，如果这个指标≥6.5%，也可作为糖尿病的诊断标准；如果该指标界于5.7%~6.4%之间，也被称为糖尿病前期。由于技术方面原因，我国尚未将糖化血红蛋白作为诊断依据。但是如果你检测此项指标有增高（特别是超过6%的时候），也应咨询医生。</span></p><p style=\"line-height: 200%; text-align: center;\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\"><img src=\"http://01luntan.com/ly_img/uimgs/1559400399461.jpg\" title=\"糖尿病前期症状与危害\" alt=\"糖尿病前期症状与危害\" width=\"600\" height=\"397\"/></span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">2. </span><span style=\"font-size:19px;line-height:200%;font-family:宋体\">糖尿病前期有啥危害？</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">顾名思义，糖尿病前期就是糖尿病的前期阶段，几乎所有2型糖尿病患者在患病前都会经历这个阶段。因此，糖尿病前期最大的危害就是逐渐发展成为糖尿病。有学者认为，与血糖正常的人群相比，糖尿病前期人群发生心血管疾病的风险明显增高，但是最近发表的一项设计严谨、规模较大的前瞻性研究并未证实这一推测（专业人士可参见：Prediabetes and Risk for Cardiac Death Among Patients With Coronary Artery Disease: The ARTEMIS Study. Diabetes Care 2019 May; dc182549)。目前看来，糖尿病前期最值得关注的并不是其心血管并发症，而是如何避免或延缓其发展为糖尿病。</span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">3. </span><span style=\"font-size:19px;line-height:200%;font-family:宋体\">糖尿病前期有啥症状？</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">除了化验发现血糖增高外，糖尿病前期的人一般不会有任何症状。</span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">4. </span><span style=\"font-size:19px;line-height:200%;font-family:宋体\">被确定为糖尿病前期的人应该怎么办？</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">虽然绝大多数2型糖尿病患者在发病前都会经历糖尿病前期阶段，但是并非所有糖尿病前期者均会发展成为糖尿病。经过积极合理的干预，很多人的血糖完全可以恢复正常。当然，如果听之任之、任其发展，很多人便会形成糖尿病。</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">确认为糖尿病前期后，最有效的干预措施就是通过控制饮食、增加运动、减轻体重来使血糖降低并恢复正常。超重或肥胖者，如果将体重减轻7%，可以使发生糖尿病的风险降低50%以上。平时运动较少的人，每天进行半个小时以上的中等强度户外运动（例如快步行走）也有此功效。即便你是个大胖子、很难将体重控制到理想范围，只要能把体重减轻10-15斤，就可大大降低发生糖尿病的风险。</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">此外，糖尿病前期的人最好每年检测一次血糖，及时了解血糖变化趋势，为制定干预方案提供依据。</span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">5. </span><span style=\"font-size:19px;line-height:200%;font-family:宋体\">确定为糖尿病前期的人需要用降糖药吗？</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">这是一个有争议的话题，不同专家持有不同的观点。但是需要说明的一个问题，以严谨和尊重证据著称的美国食药监局（FDA）迄今没有批准任何降糖药物用于糖尿病前期的治疗。</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">对于糖尿病前期，用药治疗的目的是什么？能否达到预期目的？</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">第一个目的当然是预防糖尿病前期发展为糖尿病。对于这个问题，目前仍缺乏有效的研究证据支持这种做法。服用降糖药物后血糖当然会有所下降，甚至会降到正常水平，但是停药以后呢？很多人停用降糖药后血糖会重新回复到较高水平。这就是说，这些人用降糖药只是一个治标不治本的方法。</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">第二个目的是预防心血管病。对此，国外曾经进行了数项研究，均未能证实服用降糖药可以降低这些人发生心血管病的风险。</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">无论哪一种降糖药，都会有这样或那样的副作用，花了钱买药、承担着潜在的副作用、期盼着难以实现的远大目标，似乎不太合适。</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">另外一点不容忽视：很多人以为吃了降糖药就会避免糖尿病的发生，就放松了对自己的要求，照样大吃大喝、照样懒着不动、照样大腹便便，其血糖不升高才怪呢！</span></p><p style=\"line-height:200%\"><span style=\"font-size:19px;line-height:200%;font-family:宋体\">所以说，我本人不建议糖尿病前期的人使用降糖药物治疗。唯一该做、唯一正确的只有通过控制饮食与增加运动来达到控制体重的目的</span></p><p style=\"line-height: 200%; text-align: center;\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">&nbsp;<img src=\"http://01luntan.com/ly_img/uimgs/1559399699955.jpg\" title=\"糖尿病前期症状与危害\" alt=\"糖尿病前期症状与危害\" width=\"250\" height=\"343\"/></span></p><p style=\"line-height: 200%; text-align: center;\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\"></span><span style=\"font-family: 宋体; font-size: 19px;\">欢迎扫描二维码加入QQ群，听听病友们怎么说，听听医生怎么说</span></p><p style=\"line-height: 200%;\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\"></span><br/></p><p><br/></p>","barId":"1935","topicTypeId":null,"topicThemeId":"1034","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":1,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":7},{"id":"13447","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":"得了糖尿病能生孩子吗","content":"<p style=\"margin: 5px 0;text-indent: 32px;line-height: 200%\"></p><p style=\"margin: 5px 0;text-indent: 32px;line-height: 200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">如果有糖尿病，可以生孩子吗？需要注意什么？有高人解答吗？</span></p><p><br/></p>","barId":"1935","topicTypeId":null,"topicThemeId":"1033","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":7},{"id":"12104","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":"15岁男孩吃辣条吃出糖尿病酮症酸中毒 ","content":"<p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">1月31日零时40分，在郴州市第一人民医院急诊科，一名15岁男孩紧急从永兴县马田镇医院转来，经过医院检查发现该男孩为糖尿病酮症酸中毒。为何会中毒？根据男孩父亲介绍，男孩当天食用15包辣条所致。目前男孩已经入住该院ICU抢救，其尚未脱离生命危险。</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\"><br/></span></p><p style=\"margin: 0px; text-indent: 32px; text-align: center; line-height: 200%;\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\"><img src=\"http://01luntan.com/ly_img/uimgs/1517537675609.jpg\" title=\"15岁男孩吃辣条吃出糖尿病酮症酸中毒 \" alt=\"15岁男孩吃辣条吃出糖尿病酮症酸中毒 \" width=\"600\" height=\"372\"/></span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">据男孩父亲介绍，</span>1月30日，男孩买了15包辣条吃。食用后当晚，男孩出现呕吐、腹痛、烦躁等症状，家人赶紧把他送到当地医院。男孩一度出现昏迷症状，这可把家长吓着了。由于男孩病情严重，1月31日凌晨紧急转院到第一人民医院进行救治。</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">郴州市第一人民医院急诊科主任介绍，患儿是因为进食辣条后出现了呕吐、头痛、头晕、发热、精神差等症状后由急诊科接诊转入的。</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">男孩的主治医生介绍，患儿入院时，曾出现现肝、肾脏功能损害，入院后立刻上大呼吸机辅助呼吸，男孩当时的小便是酱油色的，经过洗胃、催吐、导泻等处理后病情才相对稳定。经过急查血糖</span>Hi 尿酮阳性，确定为糖尿病酮症酸中毒，病情十分严重，该院急诊科立即将男孩转入ICU 进行救治。</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">主治医生分析，男孩是在农村的小商店购买辣条吃，而导致入院治疗，主要是因为辣条含有大量亚硝酸盐，当亚硝酸盐与血红蛋白作用时，会使二价铁氧化成三价铁，形成高铁血红蛋白，而失去携氧的能力，进而造成组织缺氧。通常情况，一般食用</span>0.2 克到0.5 克的亚硝酸盐就会引起中毒，食用1 克到2 克的话就会导致死亡。</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">主治医生介绍，辣条含有多种食品添加剂，如果长期大量食用，产生的叠加效应会对身体造成伤害。人工色素、甜味剂等摄入过量，会对人的神经系统产生影响。如果是一些小作坊生产的，卫生得不到保证，会影响孩子的健康发育。</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">专家温馨提示：各位父母除了要支持这些提议之外，还要注意给小朋友灌输正确的观念，告诉小朋友，什么是健康饮食，在饮食的过程中，怎样才能做到饮食均匀、平衡。另外，还要经常带小朋友进行体育锻炼。不然，民族的健康问题将会面临更加严峻的形势。一旦出现精神不佳、腹痛、呕吐的症状，要赶紧送医。</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"font-family: 宋体;letter-spacing: 0;font-size: 16px\">找良医网希望该男孩早日康复！别再让您的父母为你而担心！</span></p><p style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\"letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"margin-right:0;margin-left:0;text-indent:32px;text-autospace:ideograph-numeric;text-align:justify;text-justify:inter-ideograph;line-height:200%\"><span style=\";font-family:宋体;line-height:200%;font-size:16px\">&nbsp;</span></p><p><br/></p>","barId":"1935","topicTypeId":null,"topicThemeId":"1032","readLevel":0,"files":"[]","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":7},{"id":"26209","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":"发生低血糖怎么办","content":"<p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">正常人有时候在不注意的情况下，都会发生低血糖的情况，所以，糖尿病人更要注意预防，那么，</span></span><strong><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">发生低血糖怎么办</span></span></strong><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">？</span></span><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">找良医网告诉你，</span></span><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">糖尿病人比较常发生低血糖，低血糖可导致不适甚至危及生命。</span></span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;<img src=\"http://01luntan.com/ly_img/uimgs/1565688406731.jpg\" title=\"发生低血糖怎么办\" alt=\"发生低血糖怎么办\" width=\"600\" height=\"372\"/></span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">低血糖可以表现为心慌、焦虑、出汗、饥饿、注意力不集中、反应迟钝、暴躁、易怒甚至抽搐、昏迷等多种表现，老年人还常会发生行为异常，经常发生低血糖的人可能没有任何症状就直接昏迷。</span></span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">低血糖治疗的原则就是快速补糖。</span></span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">发生低血糖要马上补充任何含糖高的食物，如糖果、饼干、果汁等，如果出现了意识不清、昏迷，需要静脉注射葡萄糖等治疗，要立即就医。</span></span><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;<img src=\"http://01luntan.com/ly_img/uimgs/1565688523280.jpg\" title=\"发生低血糖怎么办\" alt=\"发生低血糖怎么办\" width=\"219\" height=\"300\"/></span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">欢迎扫描二维码加入</span>QQ群，听听病友们怎么说，听听医生怎么说！</span></p><p><br/></p>","barId":"1935","topicTypeId":null,"topicThemeId":"1029","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":8},{"id":"25235","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":"吡格列酮心脏病患者能服用吗","content":"<p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height: 200%;font-family: 宋体\">吡格列酮心脏病患者能服用吗？</span><span style=\"font-size: 19px;line-height: 200%;font-family: 宋体;letter-spacing: 0;background: white\"> 2019年国际卒中大会期间，刚刚报道了IRIS研究的亚组分析结果或许能解答大家的疑问。</span></p><p style=\"line-height: 200%; text-align: center;\"><span style=\"font-size: 19px;line-height: 200%;font-family: 宋体;letter-spacing: 0;background: white\"><img src=\"http://01luntan.com/ly_img/uimgs/1555154060525.jpg\" title=\"吡格列酮心脏病患者能服用吗\" alt=\"吡格列酮心脏病患者能服用吗\" width=\"600\" height=\"397\"/></span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height: 200%;font-family: 宋体;letter-spacing: 0;background: white\">分析结果显示伴糖尿病前期的卒中或TIA后患者，接受吡格列酮治疗可使卒中与心肌梗死发生率降低43%，卒中发生率降低36%，急性冠脉综合征减少53%，由卒中、心肌梗死和因心衰住院所组成的复合终点事件发生率降低39%，新发糖尿病降低82%。</span></p><p style=\"line-height:200%\"><span style=\"font-size: 19px;line-height: 200%;font-family: 宋体\">&nbsp;</span></p><p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">于3年前结束的IRIS研究采用多中心随机化双盲安慰剂对照设计，共纳入3876例近期发生卒中或短暂脑缺血发作、且存在胰岛素抵抗的患者，随机纳入吡格列酮（45 mg/日）或安慰剂治疗组，平均随访4.8年。主要终</span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\">点为致死性或非致死性卒中或心肌梗死。随访结果显示，与安慰剂组相比，吡格列酮治疗组患者主要终点发生率显著降低（</span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">11.8%</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">对</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">9.0%</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">，</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">HR=0.76</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">，</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">p=0.007</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">）。安慰剂组与吡格列酮组患者分别有</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">3.8%</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">和</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">7.7%</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">发生糖尿病（</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">p&lt;0.001</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">）。吡格列酮组患者体重增加、水肿、需要住院或手术治疗的骨折风险显著增高。该研究结论认为，对于伴有胰岛素抵抗且近期发生卒中</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">/</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">短暂脑缺血发作的患者，应用吡格列酮治疗可以显著降低卒中与心肌梗死风险，显著减少新发糖尿病的发生，但体重增加、水肿与骨折风险增高。</span></span></p><p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;</span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">由于该研究受试者为胰岛素抵抗患者，其评估方法为</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">HOMA-IR</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">评分，而这一评分方法在临床实践中较少应用。为了解该研究结论的具体临床意义，研究者进行了此项事后分析。这项亚组分析共纳入</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">2885</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">例糖尿病前期患者（</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">HbA1C 5.7%-6.4%</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">，或空腹血糖</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">5.6-7.0</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">），结果显示这组患者接受吡格列酮治疗获益更为显著。</span></span></span></p><p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;</span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">既往多项临床试验显示降低血糖水平难以改善</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">2</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">型糖尿病的患者的大血管预后，提示对于</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">2</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">型糖尿病患者不应仅仅着眼于降糖本身。胰岛素抵抗是</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">2</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">型糖尿病的主要病理生理机制，也是糖尿病患者发生大血管并发症的重要机制之一。</span></span></span><span style=\"font-family: 宋体; font-size: 19px;\">因此，胰岛素抵抗可能是2型糖尿病与动脉粥样硬化性心血管病发生发展的“共同土壤”。研究发现，胰岛素抵抗人群发生不良心血管事件的风险明显高于非胰岛素抵抗人群。正因如此，干预胰岛素抵抗被认为是防治糖尿病及其心血管合并症的重要靶点。对于以胰岛素抵抗为主要机制的糖尿病前期患者，改善胰岛素敏感性，有助于从更早期阶段预防糖尿病并减少其心血管并发症的发生。</span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\"></span></span></span><br/></p><p style=\"margin-top:4px;margin-right:0;margin-bottom:4px;margin-left: 0;text-align:justify;text-justify:inter-ideograph;line-height:200%;background:white\"><br/></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\"></span></span></span><br/></p>","barId":"1935","topicTypeId":null,"topicThemeId":"1028","readLevel":0,"files":"[]","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":7},{"id":"25226","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"userId":null,"title":"利格列汀能不能代替磺脲类药物","content":"<p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><strong><span style=\"font-size:19px;line-height:200%;font-family:宋体;color:#333333;letter-spacing:0;font-weight:normal\">高血压、高胆固醇血症、糖尿病被视为动脉粥样硬化性心血管疾病的三大重要危险因素。然而与高血压和血脂异常相比，关于糖尿病的临床研究证据却非常匮乏。从1970年发表的备受争议的UGDP研究之后，陆续结束的大型降糖试验包括UKPDS、DIGAMI2、PROactive、BARI 2D、ADVANCE、ACCORD、VADT、HEART2D、RECORD、ORIGIN、SAVOR-TIMI53、EXAMINE、TECOS、ELIXA、EMPA-REGOUTCOME、IRIS（受试对象为胰岛素抵抗人群）、LEADER、SUSTAIN-6、CANVAS、ACE、TOSCA IT、EXSCEL、DECLARE-TIMI58、Harmony Outcomes以及CARMELINA，总共不过26项降糖药物干预试验。并且这些研究主要完成于2007年Nissen一手炮制的“文迪雅事件”之后。如此有限的证据显然难以为流行趋势日渐猖獗的糖尿病的有效治疗提供足够支撑。正因如此，关于如何科学合理的管理血糖仍充满争议。</span></strong></p><p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;</span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">在我心目中，真正称得上具有里程碑意义的降糖治疗试验只有三项：其一，UKPDS研究，首次证实了强化降糖能够显著减少微血管并发症的发生，但不能降低大血管事件发生率；其二，EMPA-REG研究，发现恩格列净治疗能够显著降低全因死亡率与心血管死亡率，这是首项证实降糖药物治疗可以降低心血管风险的临床试验；其三，就是即将公布结果的<span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\">CAROLINA研究（Cardiovascular Outcome Study of</span></span><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">&nbsp;</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">Linagliptin</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">&nbsp;</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">VersusGlimepiride in Patients With Type 2 Diabetes</span><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">），这项研究将利格列汀与格列美脲进行头对头比较</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\">，其结果或将对降糖治疗临床实践产生重大影响。</span></span></p><p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;</span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">CAROLINA</span><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">研究旨在比较伴有心血管高危因素的2型糖尿病患者应用利格列汀或格列美脲对糖尿病并发症发生率和死亡率的影响。共纳入6103例2型糖尿病患者，年龄40-85岁，排除应用噻唑烷二酮、GLP-1、DPP-4抑制剂或任何类型胰岛素治疗的患者。将患者随机分为两组，分别接受利格列汀（5mg，QD）或格列美脲（1-4mg，QD）治疗。主要复合终点为致死性心肌梗死、非致死性心肌梗死、致死性卒中、非致死性卒中或因不稳定性心绞痛住院。</span></span></p><p style=\"margin-bottom: 0px; text-align: center; line-height: 200%; background: white;\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;<img src=\"http://01luntan.com/ly_img/uimgs/1555141064849.jpg\" title=\"利格列汀能不能代替磺脲类药物\" alt=\"利格列汀能不能代替磺脲类药物\" width=\"600\" height=\"397\"/></span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">之所以我认为这是第三项具有里程碑意义的临床试验，是因为该研究结果有可能对降糖治疗临床实践产生重要影响。现已经完成的</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">SAVOR-TIMI53</span><span style=\"font-size: 19px;line-height:200%;color:#333333;letter-spacing:0\">、EXAMINE、TECOS和CARMELINA研究已经充分证明，DPP-4抑制剂虽然不能产生心血管获益，但具有良好的心血管安全性。换言之，此类药物对于糖尿病患者的心血管预后呈中性影响，因而非常适合用作探讨其他类型降糖药物心血管安全性与有效性的参照物。另一方面，<span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\">诸多迹象表明，磺脲类药物可能对心血管系统产生潜在的不利影响，其机制主要包括两方面：其一，磺脲类药物导致低血糖的风险较大，并增加严重心律失常和心肌缺血风险，这会对心脏产生直接而显著的危害；其次，磺脲类药物不仅作用于胰岛</span>B细胞的磺脲受体，对心脏与血管的磺脲受体同样具有一定影响，并会干扰心肌缺血预适应，这可能构成此类药物对心血管系统不良影响的重要机制之一。除此之外，此类药物可以增加体重，这也是其备受诟病的缺陷之一。</span></span></span></p><p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;</span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size: 19px;line-height: 200%;color: rgb(51, 51, 51);letter-spacing: 0\">目前专门针对磺脲类药物的随机化临床试验很少。40余年前颇具争议的</span></span><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">UGDP<span style=\"font-size: 19px;line-height: 200%;letter-spacing: 0\">研究提示磺脲类药物增加糖尿病患者心血管死亡率。此后具有里程碑意义的</span>UKPDS研究亚组分析表明，与二甲双胍治疗组相比，磺脲治疗组患者不良大血管事件风险增高。然而，新近完成的TOSCA IT研究却发现磺脲类药物与噻唑烷二酮类药物对受试者主要终点事件的影响无显著差异。</span></span></p><p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;</span></p><p style=\";line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:1px\">2018</span><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:1px\">年</span></span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size:19px;line-height: 200%;color:#333333;letter-spacing:0\">发表的一项研究显示，与DPP-4抑制剂相比，磺脲类降糖药与基础胰岛素可显著增加糖尿病患者心血管事件风险（原文参见：JAMA Network Open.2018;1(8):e186125.doi:<span style=\"font-size:19px;line-height:200%;letter-spacing:0\">10.1001/jamanetworkopen.2018.6125</span><span style=\"font-size:19px;line-height:200%;letter-spacing: 0\">）。</span>这项回顾性队列研究共纳入132737例2型糖尿病患者，主要研究终点为启用二线降糖药物治疗后首次心血管事件发生率，包括充血性心力衰竭、卒中、缺血性心脏病、外周动脉疾病。结果显示，与DPP-4抑制剂相比，GLP-1激动剂、SGLT-2抑制剂和噻唑烷二酮类降糖药发生心血管终点事件的风险相似，但磺脲类药物和基础胰岛素治疗的患者心血管事件发生率分别增高36%与103%</span></span></span></p><p style=\";margin-bottom:0;line-height:200%;background:white\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;</span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">基于上述研究所见，我们有理由认为CAROLINA研究很可能会发现利格列汀与格列美脲治疗组之间主要终点事件发生率会存在显著差异，格列美脲组患者心血管预后可能会显著差于利格列汀治疗组患者。倘若出现这种结果，将会对磺脲类药物的临床地位形成严重冲击。毕竟我们降糖治疗的目的不在于降低血糖本身，而是在于降低致死致残事件的发生率。如果一种药物降糖作用很优秀，但却增加致死致残事件的风险，那么这种药的势必将会逐渐退出历史舞台。</span></span></p><p style=\";margin-bottom:0;text-align:justify;text-justify: inter-ideograph;line-height:200%;background:white\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">&nbsp;</span></p><p style=\";text-align: justify;line-height: 200%;background: white;max-width: 100%;min-height: 1em;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important\"><span style=\"font-size:19px;line-height:200%;color:#333333;letter-spacing:0\">实际上，在近年更新的国内外相关指南性文件中，磺脲类药物的临床地位已经有所降低，而GLP-1激动剂或类似物以及SGLT-2抑制剂则得到了更为积极的推荐。假若格列美脲在CAROLINA研究中落败，磺脲类药物可能真的要走向末路了。</span></span></p><p style=\"line-height: 200%; text-align: center;\"><span style=\"font-size: 19px;line-height:200%;font-family:宋体\">&nbsp;</span></p><p><br/></p>","barId":"1935","topicTypeId":null,"topicThemeId":"1026","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":0,"score":0,"partCount":0,"replayCount":0,"publishStatus":0,"publishTime":0,"isCream":null,"canReply":0,"shareUrl":null,"foodCouponVal":0,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":0,"metaSearch":null,"rn":7}],"pageObj":{"list":[],"list4Map":null,"pageBegin":0,"pageSize":5,"pageNumber":0,"totalPage":0,"totalRow":0},"loginUser":null,"replies":[],"forumUserFans":null,"herfList":[],"only":"0","topic":{"id":"26202","isDel":0,"createAt":1565602121622,"createBy":"425fdc1d2e6111e8a3d800163e04584d","createName":"求一红颜笑看余生","updateAt":0,"updateBy":null,"updateName":null,"userId":"425fdc1d2e6111e8a3d800163e04584d","title":"糖前有三多一少症状吗","content":"<p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">很多糖尿病人都不知道什么是三多一少，那么，</span></span><strong><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">糖前有三多一少症状吗</span></span></strong><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">？</span></span><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">没有三多一少的症状，就不会有糖尿病吧？</span></span><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">找良医网告诉你，</span></span><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">我们常说</span>“三多一少”（多饮、多食、多尿、消瘦）是糖尿病的症状，但很多患者并没有这些典型症状。</span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><img src=\"http://01luntan.com/ly_img/uimgs/1565602124098.jpg\" title=\"糖前有三多一少症状吗\" alt=\"糖前有三多一少症状吗\" width=\"600\" height=\"372\"/>&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">多数人可能只表现为疲劳、乏力、皮肤瘙痒等不典型的症状，甚至没有什么症状。</span></span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">所以，有典型症状的只是少数，不能根据有没有症状来判断自己是否得了糖尿病。</span></span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">有些糖尿病患者由于没有明显症状，多年不知已患糖尿病，甚至在出现了并发症的相关症状时才被诊断，比如视力下降（糖尿病眼底病变）；皮肤刺痛、发麻（糖尿病神经病变）；尿蛋白增多（糖尿病肾病）、胸痛（冠心病）等。</span></span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;</span></p><p style=\"text-indent:32px;text-autospace:ideograph-numeric;line-height:200%\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">所以，定期查血糖才是早期发现糖尿病、早期治疗、预防并发症的靠谱方法。</span></span><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\">&nbsp;<img src=\"http://01luntan.com/ly_img/uimgs/1565603032727.JPG\" title=\"糖前有三多一少症状吗\" alt=\"糖前有三多一少症状吗\" width=\"219\" height=\"300\"/></span></p><p style=\"text-indent: 32px; line-height: 200%; text-align: center;\"><span style=\"font-family: 宋体;line-height: 200%;letter-spacing: 0;font-size: 16px\"><span style=\"font-family:宋体\">欢迎扫描二维码加入</span>QQ群，听听病友们怎么说，听听医生怎么说！</span></p><p><br/></p>","barId":"1935","topicTypeId":"2","topicThemeId":"1029","readLevel":0,"files":"","clickNoLikeCount":0,"clickLikeCount":0,"clickCount":1724,"score":0,"partCount":0,"replayCount":0,"publishStatus":1,"publishTime":1565602121622,"isCream":0,"canReply":0,"shareUrl":null,"foodCouponVal":1,"emailNotice":0,"permission":0,"zlyShare":0,"status":0,"sort":0,"highlight":0,"highlightEffectTime":0,"digest":0,"digestEffectTime":0,"top":0,"topEffectTime":0,"closed":0,"stamp":0,"icon":0,"bgcolor":null,"fontcolor":null,"favtimes":0,"isAdopt":0,"adoptId":null,"sortDate":1565602121622,"metaSearch":null,"rn":null},"userAllInfo":{"id":null,"isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"username":null,"password":null,"level":0,"nickName":null,"realName":null,"signName":null,"head":null,"phone":null,"mobile":null,"wechat":null,"qq":null,"email":null,"address":null,"identityType":0,"userType":0,"isPhoneBind":0,"status":0,"accountSource":0,"isStrangerMsg":0,"departmentId":null,"departmentName":null,"sex":0,"provinceId":null,"cityId":null,"userLevel":0,"modifyNameCount":0,"forumUser":{"id":"425fdc1d2e6111e8a3d800163e04584d","isDel":0,"createAt":1521785589502,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"username":"求一红颜笑看余生","password":"zx13401068656","level":0,"nickName":"找良医网问答助手","realName":null,"signName":"找良医网问题解答专员！","head":"http://01luntan.com/ly_img/1539831954338.png","phone":null,"mobile":null,"wechat":null,"qq":null,"email":"1769604826@qq.com","address":null,"identityType":5,"userType":2,"isPhoneBind":0,"status":0,"accountSource":0,"isStrangerMsg":0,"departmentId":null,"departmentName":null,"sex":1,"provinceId":"110000","cityId":"110114","userLevel":0,"modifyNameCount":1},"forumUserActiveInfo":{"id":"4263e01a2e6111e8a3d800163e04584d","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":1564562378854,"updateBy":"425fdc1d2e6111e8a3d800163e04584d","updateName":"1769604826@qq.com","userId":"425fdc1d2e6111e8a3d800163e04584d","topicCount":760,"replayCount":2252,"favorteCount":0,"beFavorteCount":0,"creamCount":1,"focusCount":0,"fansCount":0,"integralCount":776,"foodCouponCount":0,"lastLoginTime":0,"lastLoginIp":null,"downloadCount":0,"uploadCount":0},"newPass":null,"focusBar":null,"counter":null,"forumUserIdentificateDto":null},"theme":{"id":"1029","isDel":0,"createAt":0,"createBy":null,"createName":null,"updateAt":0,"updateBy":null,"updateName":null,"topicTypeId":"2","topicTypeName":"治疗","themeName":"症状","barType":"102","schemaName":2,"reward":0},"page":1,"favorties":true,"isSelf":false,"order":"asc"}